Stem Cell research is advancing at a rapid pace and recent studies have shown that for many cell types being cultured in an environment which has oxygen concentrations closer to the physiological norm (2-5%)¹can result in:

1. smaller cells with reduced complexity²,
2. reduced spontaneous differentiation³
3. increased clonogenicity²
4. reduced spontaneous chromosomal aberration frequencies²
5. extensive propagation of specialized clonal derivative cells⁴
6. reduced heterogeneity⁵

Galaxy CO₂ Incubators offer a direct heating system which gently bathes cells in warm convectional air. In addition, we offer a highly regulated C0₂ and O₂ environments with the ability to closely mimic physiological normoxic conditions and provide the optimal results for your experiments.

The rapidly emerging Stem Cell technology requires a greater sophistication in the incubation process than traditional incubators can provide.

With the availability of three different ranges of oxygen control facility (0.1–19% O₂, 1-19% O₂, 1-95% O₂ ranges) Galaxy incubators offer stem cell scientists greater choice and flexibility in controlling cellular O₂ levels than any other brand of CO₂ incubator.

The many unique features and design innovations of Galaxy incubators make them ideal for this critical and sensitive field of study.

References:

¹ Fischer, B., and Bavister, B.D. (1993) Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits J.Reprod. Fertil. 99, 673-679

² Forsyth, N.R et al. Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities Cloning and Stem Cells. 8, No1, 16-23

³Ezashi T et al. Low O2 tensions and the prevention of differentiation of hES cells. Proc Natl Acad Sci U S A. 2005 Mar 29;102(13):4783-8. Epub 2005 Mar 16
⁴Forsyth N.R, and McWhir J. Human embryonic stem cell telomere length impacts directly on clonal progenitor isolation frequency. Rejuvenation Res. 2008 Feb;11(1):5-17
⁵Forsyth N.R et al. Transcriptome alterations due to physiological normoxic (2% O₂) culture of human embryonic stem cells. Regen Med. 2008 Nov;3(6):817-33.